Study reveals significant health benefits of golden berries in diabetic and obese rats

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In a recently published study, Dr nutrientsA group of researchers evaluated the effects of golden berry (Physalis peruviana)– Enriched diet on insulin resistance and obesity in diabetic, obese rats with metabolic syndrome.

Study: Daily consumption of golden berries (Physalis peruviana) has been shown to reverse insulin resistance and obesity progression in obese mice with metabolic syndrome.  Image Credit: Creative Family/Shutterstock.comStudy: Daily consumption of golden berry (Physalis peruviana) has been shown to prevent insulin resistance and obesity progression in obese rats with metabolic syndrome.. Image Credit: Creative Family/


Metabolic syndrome, characterized by problems such as high blood sugar and obesity, often leads to insulin resistance and can progress to type 2 diabetes. Lifestyle factors, including diet and activity level, are crucial in its development and management.

The golden berry, a nutrient-dense South American fruit, has attracted attention for its potential to combat these health problems. Rich in antioxidants, vitamins and minerals, studies indicate that golden berry consumption can significantly reduce obesity and improve insulin sensitivity.

It highlights the promise of managing metabolic disorders and underscores the importance of natural, nutrient-dense foods to maintain health. More research is needed to fully understand the mechanisms by which golden berry affects metabolic disorders and to evaluate its efficacy and safety in human populations.

About the study

In the present study, the researchers took advantage of the “Dorada” variety from AGROSAVIA, the Colombian Corporation for Agricultural Research, grown in Colombia’s Caribbean Exotic SAS. The study involved 64 Wistar rats, both male and female, housed at the Industrial University of Santander.

The aim of the study was to represent, without exclusion, the rats with and without golden berry supplementation divided into four groups based on their diet – standard and high fat.

Key parameters like abdominal circumference, body weight, height and body mass index (BMI) were closely monitored. The study also involved collection and analysis of urine and blood samples, focusing on glycemic and lipid profiles.

Organ weights, including liver, pancreas and various adipose tissues, were measured after sacrifice.

Gene expression in subcutaneous adipose tissue by targeting genes such as peroxisome proliferator-activated receptor gamma (PPARγ), fatty acid synthase (FasN), insulin receptor (INSR), and lipoprotein lipase (LPL) by real-time polymerase chain reaction (qPCR) was tested. )) involves extraction, quantification and amplification of specific ribonucleic acid (RNA).

Metabolomic analysis used a chromatography-electrospray ionization-quadrupole-orbitrap (UPLC-ESI-Q-orbitrap) system for high-resolution mass spectrometry to identify metabolites affected by golden berry consumption.

The study used Ingenuity Pathway Analysis (IPA) software to uncover biological relationships between urinary metabolites and potential health effects.

Statistical analysis was conducted using GraphPad Prism® and SPSS software, employing analysis of variance (ANOVA) and Tukey tests to assess the significance of results.

Results of the study

Physiological measurements in the study revealed significant changes in body weight of mice after dietary treatment with or without golden berries.

Specifically, the high-fat diet (HFD) group showed a significant increase in weight, with the most significant differences observed compared to the standard diet (SD) and SD with golden berries (SD-GB) groups. Sex-specific differences were also noted, particularly in the HFD group, indicating an effect of diet on body weight.

Biochemical parameters were assessed across different diets, revealing significant sex-specific variations. Glycemia levels increased significantly in the HFD group, while cholesterol levels increased in all groups, especially in the HFD group.

Triglyceride levels were also significantly increased in the HFD group compared to other diets. Adding golden berries to the diet moderated these effects, particularly in the HFD-GB group.

Low-density lipoprotein (LDL)-cholesterol and high-density lipoprotein (HDL)-cholesterol levels varied between treatments, with significant differences between pre- and post-treatment values ​​in each group.

In a study of organ and adipose tissue weights, liver, pancreas, visceral adipose tissue (VAT), brown adipose tissue (BAT), and subcutaneous adipose tissue (SAT) weights were significantly affected by diet.

The HFD group increased liver and pancreas weights, suggesting a possible moderating effect of golden berry supplementation. Adipose tissues showed similar trends, with the HFD group having higher VAT and SAT weights. However, golden berry supplementation appeared to counteract these effects, particularly in the HFD-GB group.

Key gene expressions affected by dietary variation were analyzed, revealing significant changes in INSR and FasN expression in the HFD-post group. PPARγ and LPL expressions also varied across diets, with the highest expression observed in the HFD-GB diet.

These results suggest that dietary diversity, particularly the inclusion of golden berries in the HFD, significantly affects metabolic gene regulation.

Biomarker discovery and metabolomic profiling in rats post-urinary golden berry consumption was conducted using the orthogonal signal correction partial least squares-discriminant analysis (OSC-PLS-DA) method.

This analysis identified key urinary metabolites, indicating a distinct metabolic effect of golden berry consumption. Metabolites such as beta-cyclocitral glucuronide and pipecolic acid were notable for their altered excretion patterns after golden berry consumption.

The study also elucidated the metabolic networks and biological pathways affected by golden berry consumption using IPA.

This integrative approach highlights the complex metabolic interactions arising from golden berry consumption and their potential impact on health and disease.

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