Academia’s drug discovery challenges: Exploring the “publication landfill”

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A new editorial paper is published of Oncotarget Volume 15 January 24, 2024, titled, “The Fate of Drug Discovery in Academia; Dumping in the Publication Landfill?”

In this new editorial, researcher Dr Uzma Saqib, Isaac S. Demari, Alexander G. Obukhov, Mirza S. Baig, Amiram Ariel, And Krishnan Hajela, from Devi Ahilya University, Indore, discuss drug discovery-; A tedious process that is time-consuming both to ensure that a molecule hits an effective and specific target and to ensure that the potential drug does not cause serious adverse effects. Many drug candidates fail to pass multiple checkpoints on this long journey; They lag behind in one or more aspects and never go beyond the research bench to contribute to public health. These obstacles make the drug discovery process very time-consuming, expensive and tedious.

“This approach focuses on describing the how and why of multi-million [dollar] Research efforts in drug discovery often fail to reach their full potential.”

There is no shortage of research focusing on drug discovery. They are published on a daily basis describing efforts to incorporate conventional and/or modern drug discovery technologies, including structure-based drug design (SBDD), virtual screening, high-throughput screening (HTS), artificial intelligence (AI) and cell-based. Based screening method. However, many drug development strategies are rather vague in their progress.

So, there is a big gap between drug “discovery” and “development”. This part can be attributed to the lack of coordination between academia and industry at multiple levels. A significant part of this failure results from a lack of streamlining of the drug development process.

“In the current perspective, we discuss why many therapeutic molecules do not make it into clinical studies despite being proven efficient preclinically. In addition, we discuss possible solutions to overcome this shortcoming in the drug development process.”

Source:

Journal Reference:

Saqib, U., etc. (2024). The fate of drug discovery in academia; Dumping in the publishing landfill? Oncotarget. doi.org/10.18632/oncotarget.28552.



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